解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Global warming is predicted to indirectly result in more undernutrition by threatening crop production. Whether temperature rise could affect undernutrition directly is unknown. We aim to quantify the relationship between short-term heat exposure and risk of hospitalization due to undernutrition in Brazil. ...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1002950
更新日期:2019-10-29 00:00:00
abstract:BACKGROUND:Artemisinin-based combination therapy (ACT) is recommended for uncomplicated Plasmodium vivax malaria in areas of emerging chloroquine resistance. We undertook a systematic review and individual patient data meta-analysis to compare the efficacies of dihydroartemisinin-piperaquine (DP) and artemether-lumefan...
journal_title:PLoS medicine
pub_type: 杂志文章,meta分析
doi:10.1371/journal.pmed.1002928
更新日期:2019-10-04 00:00:00
abstract::Hannah Leslie and co-authors discuss priorities in individual countries for health system reform. ...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1002946
更新日期:2019-10-03 00:00:00
abstract:BACKGROUND:Intimate partner violence (IPV) against women is a major global health issue, particularly in low- and middle-income countries (LMICs), that is associated with poor physical and mental health, but its association with breastfeeding practices is understudied. Both the World Health Organization (WHO) and the U...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1002921
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Global data indicate that women with a history of hyperglycemia first detected in pregnancy (HFDP) are at up to 7 times risk of progressing to type 2 diabetes mellitus (T2DM) compared with their counterparts who have pregnancies that are not complicated by hyperglycemia. However, there are no data from the s...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1002865
更新日期:2019-09-09 00:00:00
abstract:BACKGROUND:Various risk factors have been associated with epithelial ovarian cancer risk in observational epidemiological studies. However, the causal nature of the risk factors reported, and thus their suitability as effective intervention targets, is unclear given the susceptibility of conventional observational desi...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1002893
更新日期:2019-08-07 00:00:00
abstract:BACKGROUND:Exposure to a nutritionally deficient environment during fetal life and early infancy may adversely alter the ontogeny of the immune system and affect an infant's ability to mount an optimal immune response to vaccination. We examined the effects of maternal nutritional supplementation during pregnancy on in...
journal_title:PLoS medicine
pub_type: 杂志文章,随机对照试验
doi:10.1371/journal.pmed.1002854
更新日期:2019-08-06 00:00:00
abstract:BACKGROUND:The National Health Service (NHS) in England introduced a population-wide programme for cardiovascular disease (CVD) prevention in 2009, known as NHS Health Checks. This research aimed to measure the cardiovascular risk management and cardiovascular risk factor outcomes of the health check programme during s...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1002863
更新日期:2019-07-30 00:00:00
abstract:BACKGROUND:With no effective treatments for cognitive decline or dementia, improving the evidence base for modifiable risk factors is a research priority. This study investigated associations between risk factors and late-life cognitive decline on a global scale, including comparisons between ethno-regional groups. ME...
journal_title:PLoS medicine
pub_type: 杂志文章,meta分析,多中心研究
doi:10.1371/journal.pmed.1002853
更新日期:2019-07-23 00:00:00
abstract::[This corrects the article DOI: 10.1371/journal.pmed.1002781.]. ...
journal_title:PLoS medicine
pub_type: 已发布勘误
doi:10.1371/journal.pmed.1002880
更新日期:2019-07-18 00:00:00
abstract:BACKGROUND:Intravenous morphine (IVM) is the most common strong analgesic used in trauma, but is associated with a clear time limitation related to the need to obtain an access route. The intranasal (IN) route provides easy administration with a fast peak action time due to high vascularization and the absence of first...
journal_title:PLoS medicine
pub_type: 杂志文章,多中心研究
doi:10.1371/journal.pmed.1002849
更新日期:2019-07-16 00:00:00
abstract:BACKGROUND:The cesarean section (CS) rate has risen globally during the last two decades. Effective and feasible strategies are needed to reduce it. The aim of this study was to assess the CS rate change after a two-stage intervention package that was designed to reduce the overall CS rate in Guangzhou, China. METHODS...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1002846
更新日期:2019-07-08 00:00:00
abstract:BACKGROUND:Helminth and protozoan infections affect more than 1 billion children globally. Improving water quality, sanitation, handwashing, and nutrition could be more sustainable control strategies for parasite infections than mass drug administration, while providing other quality of life benefits. METHODS AND FIND...
journal_title:PLoS medicine
pub_type: 杂志文章,随机对照试验
doi:10.1371/journal.pmed.1002841
更新日期:2019-06-26 00:00:00
abstract:BACKGROUND:Socioeconomic disparities in infant mortality have persisted for decades in high-income countries and may have become stronger in some populations. Therefore, new understandings of the mechanisms that underlie socioeconomic differences in infant deaths are essential for creating and implementing health initi...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1002831
更新日期:2019-06-14 00:00:00
abstract:BACKGROUND:Magnetic resonance imaging (MRI) combined with targeted biopsy (TB) is increasingly used in men with clinically suspected prostate cancer (PCa), but the long acquisition times, high costs, and inter-center/reader variability of routine multiparametric prostate MRI limit its wider adoption. METHODS AND FINDI...
journal_title:PLoS medicine
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1371/journal.pmed.1002813
更新日期:2019-06-03 00:00:00
abstract:BACKGROUND:Although the success of HIV treatment programs depends on retention and viral suppression, routine program monitoring of these outcomes may be incomplete. We used data from the national electronic medical record (EMR) system in Zambia to enumerate a large and regionally representative cohort of patients on t...
journal_title:PLoS medicine
pub_type: 杂志文章,多中心研究
doi:10.1371/journal.pmed.1002811
更新日期:2019-05-31 00:00:00
abstract:BACKGROUND:Evidence on where in the hypertension care process individuals are lost to care, and how this varies among states and population groups in a country as large as India, is essential for the design of targeted interventions and to monitor progress. Yet, to our knowledge, there has not yet been a nationally rep...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1002801
更新日期:2019-05-03 00:00:00
abstract::This month in PLOS Medicine we launched a Special Issue on New Tools and Strategies for Tuberculosis Diagnosis, Care, and Elimination. In this issue's Editorial, the Guest Editors Claudia Denkinger, Richard Chaisson, and Mark Hatherill highlight some of the research that will publish and how these studies focusing on ...
journal_title:PLoS medicine
pub_type: 社论
doi:10.1371/journal.pmed.1002795
更新日期:2019-04-30 00:00:00
abstract:BACKGROUND:A nonsputum blood test capable of predicting progression of healthy individuals to active tuberculosis (TB) before clinical symptoms manifest would allow targeted treatment to curb transmission. We aimed to develop a proteomic biomarker of risk of TB progression for ultimate translation into a point-of-care ...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1002781
更新日期:2019-04-16 00:00:00
abstract:BACKGROUND:Antenatal corticosteroid therapy (ACT) is used clinically to prepare the fetal lung for impending preterm birth, but animal and human studies link corticosteroids to smaller birth size. Whether ACT is associated with birth size is debated; therefore, we assessed differences in birth size in treated versus un...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1002746
更新日期:2019-02-26 00:00:00
abstract::[This corrects the article DOI: 10.1371/journal.pmed.1002718.]. ...
journal_title:PLoS medicine
pub_type: 已发布勘误
doi:10.1371/journal.pmed.1002760
更新日期:2019-02-25 00:00:00
abstract:BACKGROUND:Psoriasis is a common inflammatory skin disease that has been reported to be associated with obesity. We aimed to investigate a possible causal relationship between body mass index (BMI) and psoriasis. METHODS AND FINDINGS:Following a review of published epidemiological evidence of the association between o...
journal_title:PLoS medicine
pub_type: 杂志文章,meta分析
doi:10.1371/journal.pmed.1002739
更新日期:2019-01-31 00:00:00
abstract::In an Editorial, Ligia Kiss and Cathy Zimmerman discuss the need for research on the prevention of human trafficking and mitigation of its effects. ...
journal_title:PLoS medicine
pub_type: 社论
doi:10.1371/journal.pmed.1002740
更新日期:2019-01-29 00:00:00
abstract:BACKGROUND:Epidemiological studies have provided compelling evidence of associations between ambient temperature and cardiovascular disease. However, evidence of effects of daily temperature variability on cardiovascular disease is scarce and mixed. We aimed to examine short-term associations between temperature variab...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1002738
更新日期:2019-01-28 00:00:00
abstract::Substantial progress has been made towards the goal of ending the HIV/AIDS epidemic due to advancements in both prevention and treatment of HIV. However, major challenges still remain. We describe basic principles of epidemic control in the context of HIV and identify a number of attainable goals in terms of control a...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1002729
更新日期:2019-01-18 00:00:00
abstract:BACKGROUND:The standard approaches to diagnosing autism spectrum disorder (ASD) evaluate between 20 and 100 behaviors and take several hours to complete. This has in part contributed to long wait times for a diagnosis and subsequent delays in access to therapy. We hypothesize that the use of machine learning analysis o...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1002705
更新日期:2018-11-27 00:00:00
abstract::Thomas Platts-Mills and Matthew Perzanowski provide their expert Perspective on a translational study from Custovic and colleagues that identifies pairings of IgE that show value in estimating risk of concurrent asthma. ...
journal_title:PLoS medicine
pub_type: 评论,杂志文章
doi:10.1371/journal.pmed.1002696
更新日期:2018-11-20 00:00:00
abstract:BACKGROUND:Electronic medical records provide large-scale real-world clinical data for use in developing clinical decision systems. However, sophisticated methodology and analytical skills are required to handle the large-scale datasets necessary for the optimisation of prediction accuracy. Myopia is a common cause of ...
journal_title:PLoS medicine
pub_type: 杂志文章,多中心研究
doi:10.1371/journal.pmed.1002674
更新日期:2018-11-06 00:00:00
abstract:BACKGROUND:Somalia has been affected by conflict since 1991, with children aged <5 years presenting a high acute malnutrition prevalence. Cash-based interventions (CBIs) have been used in this context since 2011, despite sparse evidence of their nutritional impact. We aimed to understand whether a CBI would reduce acut...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1002684
更新日期:2018-10-29 00:00:00
abstract::In a Policy Forum, Irva Hertz-Picciotto and colleagues review the scientific evidence linking organophosphate pesticides to cognitive, behavioral, and neurological deficits in children and recommend actions to reduce exposures. ...
journal_title:PLoS medicine
pub_type: 杂志文章,评审
doi:10.1371/journal.pmed.1002671
更新日期:2018-10-24 00:00:00
abstract:BACKGROUND:Evidence of the short-term effects of ambient air pollution on the risk of ischemic stroke in low- and middle-income countries is limited and inconsistent. We aimed to examine the associations between air pollution and daily hospital admissions for ischemic stroke in China. METHODS AND FINDINGS:We identifie...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1002668
更新日期:2018-10-04 00:00:00
abstract::In a Perspective, Hilary Seligman and Sanjay Basu discuss future scenarios of food assistance programs to improve population health in a changing political environment. ...
journal_title:PLoS medicine
pub_type: 评论,杂志文章
doi:10.1371/journal.pmed.1002662
更新日期:2018-10-02 00:00:00
abstract:BACKGROUND:Earlier puberty is widely linked with future obesity and cardiometabolic disease. We examined whether age at puberty onset likely influences adiposity and cardiometabolic traits independent of childhood adiposity. METHODS AND FINDINGS:One-sample Mendelian randomisation (MR) analyses were conducted on up to ...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1002641
更新日期:2018-08-28 00:00:00
abstract::[This corrects the article DOI: 10.1371/journal.pmed.1002511.]. ...
journal_title:PLoS medicine
pub_type: 杂志文章,已发布勘误
doi:10.1371/journal.pmed.1002608
更新日期:2018-06-26 00:00:00
abstract::In a Perspective, David Peiris and Dorairaj Prabhakaran discuss implications and challenges of cardiovascular disease risk assessments in the population of India. ...
journal_title:PLoS medicine
pub_type: 评论,杂志文章
doi:10.1371/journal.pmed.1002582
更新日期:2018-06-19 00:00:00
abstract::In a Policy Forum, Peter Hotez and colleagues discuss vaccination exemptions in US states and possible consequences for infectious disease outbreaks. ...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1002578
更新日期:2018-06-12 00:00:00
abstract:BACKGROUND:Tobacco addiction is a complex, multicomponent phenomenon stemming from nicotine's pharmacology and the user's biology, psychology, sociology, and environment. After decades of public denial, the tobacco industry now agrees with public health authorities that nicotine is addictive. In 2000, Philip Morris bec...
journal_title:PLoS medicine
pub_type: 历史文章,杂志文章
doi:10.1371/journal.pmed.1002562
更新日期:2018-05-01 00:00:00
abstract::In this month's editorial, the PLOS Medicine Editors discuss the role of preprints in human health research and propose a 3-part framework for ensuring benefit. ...
journal_title:PLoS medicine
pub_type: 评论,社论
doi:10.1371/journal.pmed.1002563
更新日期:2018-04-16 00:00:00
abstract:BACKGROUND:As the number of HIV-infected women initiating lifelong antiretroviral therapy (ART) during pregnancy increases globally, concerns have emerged regarding low levels of retention in HIV services and suboptimal adherence to ART during the postpartum period. We examined the impact of integrating postpartum ART ...
journal_title:PLoS medicine
pub_type: 杂志文章,随机对照试验
doi:10.1371/journal.pmed.1002547
更新日期:2018-03-30 00:00:00
abstract:BACKGROUND:Multidisciplinary care (MDC) programs have been proposed as a way to alleviate the cost and morbidity associated with chronic kidney disease (CKD) in the US. METHODS AND FINDINGS:We assessed the cost-effectiveness of a theoretical Medicare-based MDC program for CKD compared to usual CKD care in Medicare ben...
journal_title:PLoS medicine
pub_type: 杂志文章
doi:10.1371/journal.pmed.1002532
更新日期:2018-03-27 00:00:00